About us

Who are we ?

IBC is an innovative company based in France.

Our core competencies and patented technology lie at the convergence of multi-scale modeling of biological systems, artificial intelligence, machine learning, and Information and Communication Technologies. We also specialize in realizing serious games and educational resources that include animations, models, simulators and 3D graphical objects and scenes.

IBC has received numerous awards and grants in computational biology, decision-support, and serious games dedicated to Science and Education.

Our Vision

With the advent of Internet-2 that will allow virtual reality to enter every house and the fact that learning is increasingly web-based, we believe the time is right for creating advanced immersive systems for training, decision-support and research at a world class level. Initial and Continuing Education and Training within computer-based virtual environments will become widespread in both the industrialized and developing countries. In virtuo learning-by-doing and “what if” experimentation using simulators will become commonplace. Serious Games (SGs) will combine AI-based agents possessing real problem-solving and learning skills with multi-scale dynamic simulators of the systems being studied. They will spearhead this new approach to learning and training worldwide. Within the right technological frameworks, it will be possible to extend these SGs towards Decision-Support and Intelligent R&D Systems.

Our Contribution

We know from experience that one of the main obstacles to the development of advanced computer-based systems in complex domains is to establish bridges between the various specialists participating in a common project. This may include software developers, applied mathematicians, scientists, engineers and medical doctors. Our technology derives from a long history of piloting/coordinating multi-disciplinary and multi-centric projects with advanced French and European research centers (CNRS, INSERM, etc.). In addition to applying our technology to the product development processes, we will also bring our transdisciplinary competence to participate in the coordination of academic and industrial partnerships from different fields and for the benefit of all the stakeholders and final users.

We work in close collaboration with academic partners :

Partners

International Reports & Publications

European Project: Intelligent Monitoring System
  1. SIREGAR P., COATRIEUX J.L., LE BEUX P., Report on existing knowledge representation. KISS, European AIM Program, A1006-1.2.A.F.R-890717, 80 pages, Oct. 1989.
  2. MABO P., COATRIEUX J.L., SIREGAR P., Report on the definition of the evaluation domain., KISS, European AIM Program, A1006-2.1.A.F.R-890915, 12 pages, Nov. 1989.
  3. SIREGAR P., LE MOULEC F., DI RIENZO M., Initial report on knowledge representation and reasoning methods, KISS, European AIM Program, A1006-1.2.A.F.R-900321, 65 pages, March 1990.
  4. SIREGAR P., DI RIENZO M., Final report on knowledge representation and reasoning methods, KISS, European AIM Program, A1006-1.2.A.F.R-900930, 120 pages, Sept. 1990.
  5. SIREGAR P., SCHIPPERS J., Framework: Version 1, Initial reference model. KISS, European AIM Program, A1006-2.2.A-V-F-901109, 72 pages, Jan. 1990.
  6. SIREGAR P., SCHIPPERS J., COATRIEUX J.L. Framework: Version 2, Final reference model. KISS, European AIM Program, A1006-2.2.A-F-V-901130, 70 pages, Nov. 1990.
  7. FERREIRA P.J., GUEDES DE OLIVIERA P., OLIVEIRA E SILVA T., GARNER B.P., DA LUZ VIEIRA J., LE MOULEC F., SIREGAR P., Final evaluation results. KISS, European AIM Program, A1006-3.3.B-F-B-901130, 40 pages, Nov. 1990.
  8. SIREGAR P., VAN RIET R., SCHIPPERS J., BALOCCHI R., GARNER B.P., GUEDES DE OLIVIERA P., DI RIENZO M.: KISS: Knowledge Based Intelligent Signal monitoring System. A.I.M. Euroforum, Seville, Spain, pp 320-327, 1990.
Immunology, cellular and molecular biology
  1. DAVEAU M., DAVRINCHE C., JULEN N., HIRON M., ARNAUD P. and LEBRETON J.P., The synthesis of alpha-2-HS glycoprotein is down-regulated by cytokines in hepatoma HepG2 cells, FEBS Lett., 241: 191-194, 1988.
  2. RIPOCHE J., DEMARES M.J., JULEN N., LEMERCIER C., DAUCHEL H., DAVRINCHE C., DAVEAU M. and FONTAINE M., Les protéines régulatrices du système du complément, Médecine/sciences, 5: 234-243, 1989.
  3. DAUCHEL H., JULEN N., LEMERCIER C., DAVEAU M., OZANNE D., FONTAINE M. and RIPOCHE J., Expression of complement alternative pathway proteins by endothelial cells. Differential regulation by interleukin-1 and glucocorticoids, Eur. J. Immunol., 20: 1669-1675, 1990.
  4. JULEN N., DAUCHEL H., LEMERCIER C., DAVEAU M., FONTAINE M., SAUGER F., MAITROT B. and RIPOCHE J., L’exploration du système du complément. Principes généraux et perspectives, Ann. Biol. Clin.,48: 349-360, 1990.
  5. DAVEAU M., DAVRINCHE C., DJELASSI N., LEMETAYER J., JULEN N., HIRON M., ARNAUD P. and LEBRETON J.P., Partial hepatectomy and mediators of inflammation decrease the expression of liver alpha-2-HS glycoprotein gene in rats, FEBS Lett., 273: 79-81, 1990.
  6. JULEN N., DAUCHEL H., LEMERCIER C., SIM R.B., FONTAINE M. and RIPOCHE J., In vitro biosynthesis of complement factor I by human endothelial cells, Eur. J. Immunol., 22: 213-217, 1992.
  7. LEMERCIER C., JULEN N., COULPIER M., DAUCHEL H., OZANNE D., FONTAINE M. and RIPOCHE J., Differential modulation by glucocorticoids of alternative complement protein secretion in cells of the monocyte/macrophage lineage, Eur. J. Immunol., 22: 909-915, 1992.
  8. JULEN N., DAVRINCHE C., OZANNE D., LEBRETON J.-P., FONTAINE M., RIPOCHE J. and DAVEAU M., Differential modulation of complement factor H and C3 expression by TNF-alpha in the rat. In vitro and in vivo studies, Molec. Immunol., 29: 983-988, 1992.
  9. GASQUE P., JULEN N., ISCHENKO A.M., PICOT C., MAUGER C., CHAUZY C., RIPOCHE J. and FONTAINE M., Expression of complement components of the alternative pathway by glioma cell lines, J. Immunol., 149: 1381-1387, 1992.
  10. ERDEI A., JULEN N., MARSCHANG P., FEIFEL E., KEREKES K. and DIERICH M.P., A novel, complement factor H-related regulatory protein expressed on the surface of human B-cell lines, Eur. J. Immunol., 24: 867-872, 1994.
  11. JULEN N., JANATOVA J., MUR E., WENT P., RIPOCHE J. and DIERICH M.P., Degradation of complement component C3 in joint fluid from rheumatoid arthritis patients is reduced by cathepsin G and consecutive factors H and I of the complement system,Int. J. Immunopathol. Pharmacol., 7: 7-20, 1994.
  12. LARCHER C., JULEN N., PRODINGER W.M., TOETSCH M., GUERTLER L. and DIERICH M.P., Reduced CD21 (CR2) and CD54 (ICAM-1) expression in MT2 cells with HIV-1 or HIV-2 strains, Immunology Letters, 31-36, 1995.
Multi-scale quantitative and qualitative modeling
  1. SIREGAR P. Concept discovery in qualitative biophysics: A primer for quantitative biophysics, 1st European Conf. onCellular Engineering, Nice, France, 1991.
  2. SIREGAR P., LE MOULEC F.: Modeling the heart’s electrical activity: a qualitative-analog approach. Proc. IEEE Eng. in Medicine and Biology Soc. (EMBS 91), Orlando, pp 1052-1053, 1991.
  3. SIREGAR P., CHAHINE M., LEMOULEC F., LE BEUX P. An Interactive Qualitative Model in Cardiology, Comput Biomed Res, Vol. 28, 443-478, 1995.
  4. SIREGAR P., Theoretical Cardiology: From Mathematical to Qualitative Models. J. Biol. Sys., Vol 4, 131-150, 1996.
  5. SIREGAR P., SINTEFF J.P, CHAHINE M., LE BEUX P., A Cellular Automata of the Heart and its coupling with a Qualitative Model, Comput Biomed Res, Vol 29, N03, 222-246, 1996.
  6. SIREGAR P., SINTEFF J.P., JULEN N., LE BEUX P., An interactive 3D anisotropic cellular automata model of the heart,Comput. Biomed. Res., Vol. 31, 323-347, 1998.
  7. BIGOIN T., SIREGAR P., SINTEFF J.P., JULEN N., LE BEUX P., LESSARD Y., Mechanism of ventricular arrhythmias in the hypertrophied heart of rats : 3D computational model assessment, Arch. Mal. Coeur et Vaisseaux, 94, 4 : 365, 2001.
  8. SIREGAR P., JULEN N., SINTEFF J.P., Computational Integrative Physiology: At the Convergence of the Life, Physical and Computational Sciences. Proceedings of the Dec 14th 2001 meeting of the European Commission on ‘Synergy between Research in Medical-Informatics, Bio-informatics and Neuro-Informatics’, Brussels, 2002.
  9. SIREGAR P., JULEN N., SINTEFF J.P., Computational Integrative Physiology: At the Convergence of the Life, Physical and Computational Sciences, Methods of Information in Medicine, 42:177-84, 2003.
  10. SIMEONOV P.L., BREZINA, E., COTTAM, EHRESMANN, A. C., GARE, A., GORANSON, T., GOMEZ-RAMIREZ, J., JOSEPHSON, B. D., MARCHAL, B., MATSUNO, K., ROOT-BERNSTEIN, R. S., RÖSSLER, O. E., SALTHE, SCHROEDER, M., S. N., SEAMAN, B., SIREGAR P., SMITH, L. S. Stepping Beyond the Newtonian Paradigm in Biology. Towards an Integrable Computational Model of Life: Accelerating Discovery in the Biological Foundations of Science. INBIOSA White Paper. In: Integral Biomathics: Tracing the Road to Reality, P. L. Simeonov, L. S. Smith, A. C. Ehresmann (Eds.), Springer-Verlag, Heidelberg, ISBN-10: 3642281109; ISBN-13: 978-3642281105, 2012.
  11. SIMEONOV P.L., GOMEZ-RAMIREZ J., SIREGAR P., On some recent insights in Integral Biomathics, ProgBiophys Mol Biol. 2013 Sep;113(1):216-28.
Parallel computing & Simulation
  1. CAUX J., SIREGAR P., HILL D., “Accelerating 3D Cellular automata computation with GP GPU in the context of multiscale integrative biology”, Chapter 20 in Cellular Automata – Innovative Modelling for Science and Engineering, Alejandro Salcido Ed., ISBN: 978-953-307-172-5, InTech, 2011, pp. 411-426.
  2. PASSERAT-PALMBACH J., CAUX J., SIREGAR P., MAZEL C., HILL D., “Warp-Level Parallelism : Enabling Multiple Replications in Parallel on GPU”, Proceding of the 2011 EuroPean Simulation and Modelling Conference, Oct. 24-24, Guimarães, Portugal, pp. 76-83, Best paper award.
  3. CAUX J., SIREGAR P., HILL D., “Hash Life algorithm on 3D excitable medium Application to Integrative Biology”, ACM SIGSIM/SCS Summer Computer Simulation Conference, 11-1 July, 2010, Ottawa Canada, pp. 387-393.
  4. CAUX J., HILL D. and SIREGAR P., “Accelerating 3D Cellular automata computation with GP-GPU in the context of integrative biology”, In Research Report LIMOS/RR-10-10, April 2010, HAL Id: hal-00679045.
  5. PASSERAT-PALMBACH J., SCHWEITZER P., CAUX J., SIREGAR P., MAZEL C., HILL D., Harnessing Aspect Oriented Programming on GPU: Application to Warp-Level Parallelism (WLP) , International Journal of Computer Aided Engineering and Technology, 2015, 7 (2), pp.158-175
Computational chemistry
  1. BENKAIDALI L., ANDRE F., MAOUCHE B, SIREGAR P., BENYETTOU M., MAUREL F., PETITJEAN M. Computing cavities, channels, pores and pockets in proteins from non-spherical ligands models, Bioinformatics, 2014 Mar 15;30(6):792-800.
Artificial intelligence and modeling
  1. SIREGAR P., Le MOULEC F., SCHIPPERS J., MABO P., SEVERI S.: Shallow and deep knowledge in coronary care unit. 1st European Conf. on Biomedical Engineering, Nice, pp 231-232, 1991.
  2. SIREGAR P., TOULOUSE P.: Model-based Diagnosis of Brain Disorders: A Prototype Framework, Artificial Intelligence in Medicine, 7: 315-342, 1995.
  3. SIREGAR P., SINTEFF J.P., Introducing Spatio-temporal reasoning into the inverse problem in electroencephalography, Artificial Intelligence in Medicine, vol 8, 97-122, 1996.
  4. SIREGAR P., SINTEFF J.P., JULEN N., LE BEUX P., Spatio-Temporal Reasoning For Multi-scale Modeling in Cardiology, Special Issue on Cardiovascular Systems, Artificial Intelligence in Medicine, Vol. 10, 41-57, 1997.
Ontologies, decision support and intelligent medical devices
  1. CARRAULT G., KIANI H., GARREAU M., SIREGAR P., COATRIEUX J.-L., “SESAME: Système Expert Signal Analyse de données en Myographie”, Innov. Tech. Biol. Med., 8(2):121-133, 1987.
  2. GARREAU M., BELLANGER J.J., COATRIEUX J.-L., SIREGAR P.: Décomposition du signal électromyographique par une approche intelligence artificielle. Special Issue on Expert Systems in Medicine, J.L. Coatrieux Ed., Innov. Tech. Biol. Med., 8(2):133-137, 1987.
  3. SIREGAR P., TOULOUSE P., CARRAULT G., LE NOACH R., COATRIEUX J.-L.: Localization of epileptogenic process: a simulation study. Proc. IEEE EMBS, New-Orleans, pp 1448-1449, 1988.
  4. SIREGAR P., LE NOACH R., SCARABIN J.-M., COATRIEUX J.-L, Problème inverse et stabilité en électroencéphalographie. Innov. Tech. Biol. Med., 10(6):643-658, 1989.
  5. SIREGAR P., MABO P., COATRIEUX J.L., How can deep knowledge be used in CCU Monitoring? Special Issue on Intelligent Monitoring Systems, IEEE Eng. Med. Biol., Vol. 4, N0 12, 92-99, 1993.
Information Technologies and Education
  1. SIREGAR P., CHAHINE M., SINTEFF J.P. and LE BEUX P., Deep knowledge and Computer-Assisted Instruction in Cardiology. Proc. 8th World Congress on Medical Informatics, MEDINFO 95, Vancouver, Canada, 1237-1240, 1995.
  2. JULEN N., SIREGAR P., SINTEFF J.P., LE BEUX P., A qualitative model for Computed-Assisted Instruction in Cardiology, AMIA, Orlando, 1998.
  3. BURGUN A., LE DUFF F., FRESNEL A., SIREGAR P., JULEN N., GROBOIS B., EDAN G., GUILLE F., LE BEUX P., Vers l’intégration des NTIC dans une approche pédagogique par problème en médecine. Informatique et Santé, 2000, 12, 185-194.
  4. LESSARD Y., SINTEFF J.P., JULEN N., LE BEUX P., SIREGAR P., Dynamic simulations with a 3D computational model of heart for teaching physiology and cardiology. Eur J Physiol, 442, 5 : R89, 2001.
  5. LESSARD Y., JULEN N., SINTEFF J.P., LE BEUX P., SIREGAR P., Dynamic simulations with a 3D computational model of heart for teaching pharmacology. 6th Joint meeting of Société Française de Pharmacologie (SFP) and Pharmacological Societies of Brazil and Portugal, Rennes, 2002.
  6. LESSARD Y., JULEN N., SINTEFF J.P., LE BEUX P., SIREGAR P., Dynamic simulations with a 3D computational model of heart for teaching physiology and cardiology. 70th annual meeting Société de Physiologie, Quebec, Canada, 2002.
  7. SIREGAR P., JULEN N., SINTEFF J.P., LESSARD Y., Medical Advisor, un professeur virtuel dédié à l’approche pédagogique par problèmes, IPM 2003, 2ème séminaire international Internet et Pédagogie Médicale, 2003.
  8. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., Création et développement d’un campus numérique de Physiologie, IPM 2004, 3ème séminaire international Internet et Pédagogie Médicale, 2004.
  9. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., Nouveaux modes d’acquisition des connaissances médicales : le Campus Numérique de Physiologie, IPM 2005, 4ème séminaire international Internet et Pédagogie Médicale, Rennes, 1-2 décembre 2005.
  10. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., Campus Numérique de Physiologie : learning from multimedia, P2T 2006, 1er congrès commun de Physiologie, Pharmacologie et Thérapeutique, Montpellier, 10-12 avril 2006. Fundam. Clin. Pharmacol. 2006, 20 : 53.
  11. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., Des ressources multimédia pour l’enseignement de la physiologie, CIUEN 2006, Colloque International Université à l’Ere du Numérique, Paris, 22-24 mai 2006.
  12. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., Multimedia and physiology: a new way to ensure the quality of medical education and medical knowledge. MIE 2006, Maastricht, The Netherlands, August 27-30 2006. Stud Health Technol Inform 124: 899-904, 2006.
  13. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., HANNOUCHE F., RIO S., An ECG analysis interactive training system for understanding arrhythmias In Studies in Health Technology and Informatics (Proceedings of MIE 2009 Sarajevo), 150:931-935, 2009.
  14. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., Computer simulation and medical education: complementary tools for the third millennium, MEDINFO 2007, Brisbane, Australia.
  15. LESSARD Y., SIREGAR P., JULEN N., SINTEFF J.P., LE BEUX P., HANNOUCHE F., RIO S., An ECG analysis interactive training system for understanding arrhythmias. XXII International conference of the European Federation for Medical Informatics (MIE 2009) Sarajevo, Aug. 30. – Sept. 2. 2009.